Prof. Dr. med. Sergiu Groppa

Funktionen: Leiter der Sektion Bewegungsstörungen und
Neurostimulation
Tel: +49 (0) 6131 17 2998
Fax: +49 (0) 6131 17 47 2998

Curriculum Vitae

Studium

  • Rheinische Friedrich-Wilhelms-Universität Bonn
  • Leopold-Franzens-Universität Innsbruck
  • Christian-Albrechts-Universität Kiel

Wiss-Mitarbeiter:

  • Neurologische Uniklinik Kiel, Prof. G. Deuschl.
  • Labor für Neurostimulation und Bildgebung, Prof. H. Siebner
  • SFB 654, Prof. L. Marschall, Prof. J. Born
  • MND, King’s College London, Prof. N. Leigh

Ausbildung:

   Facharzt für Neurologie

Oberarzt:

   Oberarzt Neurologische Universitätsklinik Mainz

Zertifikat:

   Zertifikat der Dt. Gesellschaft für Dystonie

Leitung:

   Leitung der Sektion für Bewegungsstörungen und Neurostimulation

Promotion:

   ’’Excitability of the Motor Cortex in Photosensitive Subjects with and without idiopathic generalized Epilepsy’’. Klinik für Neuropädiatrie, Universitätsklinikum Kiel, Prof. U. Stephani (magna cum laude), 2008

Habilitation:

   „Untersuchungen zur effektiven und strukturellen Konnektivität im motorischen System an Gesunden und Patienten mit generalisierten Epilepsien,“ 2013

Professur:

Seit November 2014, Professur für Neurologie mit Schwerpunkt Bewegungsstörungen an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz

Preise, Stipendien und Auszeichnungen

2014

Top 10 der meistzitierten Manuskripte der „Clinical Neurophysiology“.

2012

1er Posterpreis, DGKN, Köln.

2012

1er Platz der meistgelesenen Manuskripte der „Klinische Neurophysiologie“, Thieme Verlag.

2011

Reisestipendium der Movement Disorders Society.

2009

Reisestipendium der Human Brain Mapping Organisation (OHBM).

2009

Reisestipendium vom deutschen akademischen Austauschdienst (DAAD).

2004 – 2007

Stipendiat der Friedrich-Ebert Stiftung, Bonn.

2000 – 2001

Stipendiat der DESITIN GmbH Stiftung, Hamburg.

Publikationen

Pubmed

Fleischer V, Radetz A, Ciolac D, Muthuraman M, Gonzalez-Escamilla G, Zipp F, Groppa S. Graph theoretical framework of brain networks in multiple sclerosis: A review of concepts. Neuroscience https://www.sciencedirect.com/science/article/pii/S0306452217307613.

Uphaus T, Oberwittler C, Groppa S, Zipp F, Bittner S. (2017): Disease reactivation after switching from natalizumab to daclizumab. J Neurol http://dx.doi.org/10.1007/s00415-017-8622-9.

Muthuraman M, Deuschl G, Koirala N, Riedel C, Volkmann J, Groppa S. (2017): Effects of DBS in parkinsonian patients depend on the structural integrity of frontal cortex. Sci Rep 7:43571 http://dx.doi.org/10.1038/srep43571.

Kolber P, Droby A, Roebroeck A, Goebel R, Fleischer V, Groppa S, Zipp F. (2017): A „kissing lesion“: In-vivo 7T evidence of meningeal inflammation in early multiple sclerosis. Mult Scler 23(8):1167-1169 http://dx.doi.org/10.1177/1352458516683267.

Koirala N, Fleischer V, Glaser M, Zeuner KE, Deuschl G, Volkmann J, Muthuraman M, Groppa S. (2017): Frontal Lobe Connectivity and Network Community Characteristics are Associated with the Outcome of Subthalamic Nucleus Deep Brain Stimulation in Patients with Parkinson’s Disease. Brain Topogr http://dx.doi.org/10.1007/s10548-017-0597-4.

Kalisch R, Baker D, Basten U, Boks M, Bonanno G, Brummelman E, Chmitorz A, Fernàndez G, Fiebach C, Galatzer-Levy I. Groppa S, et al.  (2017): The resilience framework as a strategy to combat stress-related disorders. Nature Human Behaviour

Hanganu A, Muthuraman M, Chirumamilla VC, Koirala N, Paktas B, Deuschl G, Zeuner KE, Groppa S. (2017): Correction: Grey Matter Microstructural Integrity Alterations in Blepharospasm Are Partially Reversed by Botulinum Neurotoxin Therapy. PLoS One 12(2):e0172374 http://dx.doi.org/10.1371/journal.pone.0172374.

Gracien R-M, Reitz SC, Wagner M, Mayer C, Volz S, Hof S-M, Fleischer V, Droby A, Steinmetz H, Groppa S, Hattingen E, Klein JC, Deichmann R. (2017b): Comparison of two quantitative proton density mapping methods in multiple sclerosis. MAGMA 30(1):75-83 http://dx.doi.org/10.1007/s10334-016-0585-9.

Gracien R-M, Reitz SC, Hof S-M, Fleischer V, Droby A, Wahl M, Steinmetz H, Groppa S, Deichmann R, Klein JC. (2017a): Longitudinal quantitative MRI assessment of cortical damage in multiple sclerosis: A pilot study. J Magn Reson Imaging 46(5):1485-1490 http://dx.doi.org/10.1002/jmri.25685.

Fleischer V, Gröger A, Koirala N, Droby A, Muthuraman M, Kolber P, Reuter E, Meuth SG, Zipp F, Groppa S. (2017b): Increased structural white and grey matter network connectivity compensates for functional decline in early multiple sclerosis. Mult Scler 23(3):432-441 http://dx.doi.org/10.1177/1352458516651503.

Fleischer V, Friedrich M, Rezk A, Bühler U, Witsch E, Uphaus T, Bittner S, Groppa S, Tackenberg B, Bar-Or A, Zipp F, Luessi F. (2017a): Treatment response to dimethyl fumarate is characterized by disproportionate CD8+ T cell reduction in MS. Mult Scler:1352458517703799 http://dx.doi.org/10.1177/1352458517703799.

Chirumamilla VC, Koirala N, Groppa S. (2017b): Combining transcranial magnetic stimulation and subdural electrodes for pain modulation. Clin Neurophysiol 128(6):1041-1042 http://dx.doi.org/10.1016/j.clinph.2017.03.003.

Chirumamilla V, Gonzalez-Escamilla G, Kumar S, Longfei X, Groppa S, Muthuraman M. (2017a): Establishing and validating a new source analysis method using phase. Conf Proc IEEE Eng Med Biol Soc 2017:2778-2781 http://dx.doi.org/10.1109/EMBC.2017.8037433.

Chiosa V, Groppa SA, Ciolac D, Koirala N, Mişina L, Winter Y, Moldovanu M, Muthuraman M, Groppa S. (2017): Breakdown of Thalamo-Cortical Connectivity Precedes Spike Generation in Focal Epilepsies. Brain Connect 7(5):309-320 http://dx.doi.org/10.1089/brain.2017.0487.

Vogt J, Yang JW, Mobascher A, Cheng J, Li Y, Liu X, Baumgart J, Thalman C, Kirischuk S, Unichenko P, Horta G, Radyushkin K, Stroh A, Richers S, Sahragard N, Distler U, Tenzer S, Qiao L, Lieb K, Tuscher O, Binder H, Ferreiros N, Tegeder I, Morris AJ, Gropa S, Nurnberg P, Toliat MR, Winterer G, Luhmann HJ, Huai J, Nitsch R. (2016): Molecular cause and functional impact of altered synaptic lipid signaling due to a prg-1 gene SNP. EMBO molecular medicine 8(1):25-38

Muthuraman M, Hartwigsen G, Groppa S. (2016d): (Non-) invasive mapping of cortical language areas. Clin Neurophysiol 127(3):1762-3 http://dx.doi.org/10.1016/j.clinph.2015.12.006.

Muthuraman M, Groppa S, Deuschl G. (2016c): Cerebello-cortical networks in orthostatic tremor. Brain 139(Pt 8):2104-6 http://dx.doi.org/10.1093/brain/aww164.

Muthuraman M, Fleischer V, Kolber P, Luessi F, Zipp F, Groppa S. (2016b): Structural Brain Network Characteristics Can Differentiate CIS from Early RRMS. Front Neurosci 10:14 http://dx.doi.org/10.3389/fnins.2016.00014.

Muthuraman M, Chirumamilla CV, Groppa S. (2016a): Establishing standards for neuronavigated TMS in research and clinical studies. Clin Neurophysiol 127(8):2890-1 http://dx.doi.org/10.1016/j.clinph.2016.05.009.

Koirala N, Fleischer V, Granert O, Deuschl G, Muthuraman M, Groppa S. (2016): Network effects and pathways in Deep brain stimulation in Parkinson’s disease. Conf Proc IEEE Eng Med Biol Soc 2016:5533-5536 http://dx.doi.org/10.1109/EMBC.2016.7591980.

Keshavan A, Paul F, Beyer MK, Zhu AH, Papinutto N, Shinohara RT, Stern W, Amann M, Bakshi R, Bischof A, Carriero A, Comabella M, Crane JC, D’Alfonso S, Demaerel P, Dubois B, Filippi M, Fleischer V, Fontaine B, Gaetano L, Goris A, Graetz C, Gröger A, Groppa S, Hafler DA, Harbo HF, Hemmer B, Jordan K, Kappos L, Kirkish G, Llufriu S, Magon S, Martinelli-Boneschi F, McCauley JL, Montalban X, Mühlau M, Pelletier D, Pattany PM, Pericak-Vance M, Cournu-Rebeix I, Rocca MA, Rovira A, Schlaeger R, Saiz A, Sprenger T, Stecco A, Uitdehaag BMJ, Villoslada P, Wattjes MP, Weiner H, Wuerfel J, Zimmer C, Zipp F, AIVINSON@PARTNERS.ORG IMSGCEa, Hauser SL, Oksenberg JR, Henry RG. (2016): Power estimation for non-standardized multisite studies. Neuroimage 134:281-294 http://dx.doi.org/10.1016/j.neuroimage.2016.03.051.

Groppa S. (2016): Multifocal TMS for temporo-spatial description of cortico-cortical connectivity patterns. Clin Neurophysiol 127(2):1005-1006 http://dx.doi.org/10.1016/j.clinph.2015.07.012.

Gracien R-M, Jurcoane A, Wagner M, Reitz SC, Mayer C, Volz S, Hof S-M, Fleischer V, Droby A, Steinmetz H, Groppa S, Hattingen E, Deichmann R, Klein JC. (2016): Multimodal quantitative MRI assessment of cortical damage in relapsing-remitting multiple sclerosis. J Magn Reson Imaging 44(6):1600-1607 http://dx.doi.org/10.1002/jmri.25297.

Fleischer V, Kolb R, Groppa S, Zipp F, Klose U, Gröger A. (2016): Metabolic Patterns in Chronic Multiple Sclerosis Lesions and Normal-appearing White Matter: Intraindividual Comparison by Using 2D MR Spectroscopic Imaging. Radiology 281(2):536-543 http://dx.doi.org/10.1148/radiol.2016151654.

Droby A, Yuen KSL, Muthuraman M, Reitz S-C, Fleischer V, Klein J, Gracien R-M, Ziemann U, Deichmann R, Zipp F, Groppa S. (2016): Changes in brain functional connectivity patterns are driven by an individual lesion in MS: a resting-state fMRI study. Brain Imaging Behav 10(4):1117-1126 http://dx.doi.org/10.1007/s11682-015-9476-3.

Deppe M, Krämer J, Tenberge J-G, Marinell J, Schwindt W, Deppe K, Groppa S, Wiendl H, Meuth SG. (2016): Early silent microstructural degeneration and atrophy of the thalamocortical network in multiple sclerosis. Hum Brain Mapp 37(5):1866-79 http://dx.doi.org/10.1002/hbm.23144.

Chirumamilla VC, Fleischer V, Droby A, Anjum T, Muthuraman M, Zipp F, Groppa S. (2016): Functional connectivity analysis using whole brain and regional network metrics in MS patients. Conf Proc IEEE Eng Med Biol Soc 2016:4039-4042 http://dx.doi.org/10.1109/EMBC.2016.7591613.

Anwar AR, Hashmy MY, Imran B, Riaz MH, Mehdi SMM, Muthalib M, Perrey S, Deuschl G, Groppa S, Muthuraman M. (2016): Complex network analysis of resting-state fMRI of the brain. Conf Proc IEEE Eng Med Biol Soc 2016:3598-3601 http://dx.doi.org/10.1109/EMBC.2016.7591506.

Alexandru H, Muthuraman M, Chirumamilla VC, Koirala N, Paktas B, Deuschl G, Zeuner KE, Groppa S. (2016): Grey Matter Microstructural Integrity Alterations in Blepharospasm Are Partially Reversed by Botulinum Neurotoxin Therapy. PLoS One 11(12):e0168652 http://dx.doi.org/10.1371/journal.pone.0168652.

Muthuraman M, Anjum T, Droby A, Fleischer V, Reitz S, Mideksa K, Schmidt G, Zipp F, Groppa S. (2015): Testing different ICA algorithms and connectivity analyses on MS patients. Conf Proc IEEE Eng Med Biol Soc 2015:4314-7 http://dx.doi.org/10.1109/EMBC.2015.7319349.

Hanganu A, Groppa SA, Deuschl G, Siebner H, Moeller F, Siniatchkin M, Stephani U, Groppa S. (2015): Cortical Thickness Changes Associated with Photoparoxysmal Response. Brain Topogr 28(5):702-709 http://dx.doi.org/10.1007/s10548-014-0353-y.

Chaitanya CV, Koirala N, Mideksa KG, Anwar AR, Schmidt G, Deuschl G, Groppa S, Muthuraman M. (2015): Testing the effects of pre-processing on voxel based morphometry analysis. Conf Proc IEEE Eng Med Biol Soc 2015:4302-5 http://dx.doi.org/10.1109/EMBC.2015.7319346.

Groppa S, Herzog J, Falk D, Riedel C, Deuschl G, Volkmann J. (2014): Physiological and anatomical decomposition of subthalamic neurostimulation effects in essential tremor. Brain 137(Pt 1):109-21 http://dx.doi.org/10.1093/brain/awt304.

Groppa S. (2014): U-shape effects of lithium on motor cortex excitability or possible mechanisms of an „old“ first line therapy. Clin Neurophysiol 125(11):2144-5 http://dx.doi.org/10.1016/j.clinph.2014.04.006.

Muthuraman M, Hellriegel H, Groppa S, Deuschl G, Raethjen J. (2013): The cortical and sub-cortical network of sensory evoked response in healthy subjects. Conf Proc IEEE Eng Med Biol Soc 2013:5369-72 http://dx.doi.org/10.1109/EMBC.2013.6610762.

Groppa S, Muthuraman M, Otto B, Deuschl G, Siebner HR, Raethjen J. (2013): Subcortical substrates of TMS induced modulation of the cortico-cortical connectivity. Brain Stimul 6(2):138-46 http://dx.doi.org/10.1016/j.brs.2012.03.014.

Chiosa V, Granziera C, Spinelli L, Pollo C, Roulet-Perez E, Groppa S, Seeck M. (2013): Successful surgical resection in non-lesional operculo-insular epilepsy without intracranial monitoring. Epileptic Disord 15(2):148-57 http://dx.doi.org/10.1684/epd.2013.0581.

Muthuraman M, Paschen S, Hellriegel H, Groppa S, Deuschl G, Raethjen J. (2012): Locating the STN-DBS electrodes and resolving their subsequent networks using coherent source analysis on EEG. Conf Proc IEEE Eng Med Biol Soc 2012:3970-3 http://dx.doi.org/10.1109/EMBC.2012.6346836.

Groppa S, Werner-Petroll N, Münchau A, Deuschl G, Ruschworth MFS, Siebner HR. (2012d): A novel dual-site transcranial magnetic stimulation paradigm to probe fast facilitatory inputs from ipsilateral dorsal premotor cortex to primary motor cortex. Neuroimage 62(1):500-9 http://dx.doi.org/10.1016/j.neuroimage.2012.05.023.

Groppa S, Schlaak BH, Münchau A, Werner-Petroll N, Dünnweber J, Bäumer T, van Nuenen BFL, Siebner HR. (2012c): The human dorsal premotor cortex facilitates the excitability of ipsilateral primary motor cortex via a short latency cortico-cortical route. Hum Brain Mapp 33(2):419-30 http://dx.doi.org/10.1002/hbm.21221.

Groppa S, Oliviero A, Eisen A, Quartarone A, Cohen LG, Mall V, Kaelin-Lang A, Mima T, Rossi S, Thickbroom GW, Rossini PM, Ziemann U, Valls-Solé J, Siebner HR. (2012b): A practical guide to diagnostic transcranial magnetic stimulation: report of an IFCN committee. Clin Neurophysiol 123(5):858-82 http://dx.doi.org/10.1016/j.clinph.2012.01.010.

Groppa S, Moeller F, Siebner H, Wolff S, Riedel C, Deuschl G, Stephani U, Siniatchkin M. (2012a): White matter microstructural changes of thalamocortical networks in photosensitivity and idiopathic generalized epilepsy. Epilepsia 53(4):668-76 http://dx.doi.org/10.1111/j.1528-1167.2012.03414.x.

Depienne C, Bouteiller D, Méneret A, Billot S, Groppa S, Klebe S, Charbonnier-Beaupel F, Corvol J-C, Saraiva J-P, Brueggemann N, Bhatia K, Cincotta M, Brochard V, Flamand-Roze C, Carpentier W, Meunier S, Marie Y, Gaussen M, Stevanin G, Wehrle R, Vidailhet M, Klein C, Dusart I, Brice A, Roze E. (2012): RAD51 haploinsufficiency causes congenital mirror movements in humans. Am J Hum Genet 90(2):301-7 http://dx.doi.org/10.1016/j.ajhg.2011.12.002.

Groppa S, Herzog J, Falk D, Riedel C, Deuschl G, Volkmann J. (2011b): Kinematic analysis and MR-tractography for elucidating the effect of deep brain stimulation in essential tremor. Movement Disorders 26:S243-S244.

Groppa S, Ghobadi Z, Hanganu A, Siebner H, Deuschl G. (2011a): Probing ipsilateral connectivity between posterior parietal and primary motor cortex at high temporal resolution with dual-site TMS. Akt Neurol

Granert O, Peller M, Gaser C, Groppa S, Hallett M, Knutzen A, Deuschl G, Zeuner KE, Siebner HR. (2011): Manual activity shapes structure and function in contralateral human motor hand area. Neuroimage 54(1):32-41 http://dx.doi.org/10.1016/j.neuroimage.2010.08.013.

Depienne C, Cincotta M, Billot S, Bouteiller D, Groppa S, Brochard V, Flamand C, Hubsch C, Meunier S, Giovannelli F, Klebe S, Corvol JC, Vidailhet M, Brice A, Roze E. (2011): A novel DCC mutation and genetic heterogeneity in congenital mirror movements. Neurology 76(3):260-4 http://dx.doi.org/10.1212/WNL.0b013e318207b1e0.

Verleger R, Möller F, Kuniecki M, Smigasiewicz K, Groppa S, Siebner HR. (2010): The left visual-field advantage in rapid visual presentation is amplified rather than reduced by posterior-parietal rTMS. Exp Brain Res 203(2):355-65 http://dx.doi.org/10.1007/s00221-010-2237-z.

Groppa S, Peller M, Siebner HR. (2010b): Functional Assessment of Corticospinal Conduction with Transcranial Magnetic Stimulation: Basic Principles. Klin. Neurophysiol. 41(1):12-22.

Groppa S, Bergmann TO, Siems C, Mölle M, Marshall L, Siebner HR. (2010a): Slow-oscillatory transcranial direct current stimulation can induce bidirectional shifts in motor cortical excitability in awake humans. Neuroscience 166(4):1219-25 http://dx.doi.org/10.1016/j.neuroscience.2010.01.019.

Zeuner KE, Peller M, Knutzen A, Groppa S, Holler I, Kopper F, Raethjen J, Dressler D, Hallett M, Deuschl G, Siebner HR. (2009): Slow pre-movement cortical potentials do not reflect individual response to therapy in writer’s cramp. Clin Neurophysiol 120(6):1213-9 http://dx.doi.org/10.1016/j.clinph.2009.04.010.

Siebner HR, Bergmann TO, Bestmann S, Massimini M, Johansen-Berg H, Mochizuki H, Bohning DE, Boorman ED, Groppa S, Miniussi C, Pascual-Leone A, Huber R, Taylor PCJ, Ilmoniemi RJ, De Gennaro L, Strafella AP, Kähkönen S, Klöppel S, Frisoni GB, George MS, Hallett M, Brandt SA, Rushworth MF, Ziemann U, Rothwell JC, Ward N, Cohen LG, Baudewig J, Paus T, Ugawa Y, Rossini PM. (2009): Consensus paper: combining transcranial stimulation with neuroimaging. Brain Stimul 2(2):58-80 http://dx.doi.org/10.1016/j.brs.2008.11.002.

Pötter-Nerger M, Fischer S, Mastroeni C, Groppa S, Deuschl G, Volkmann J, Quartarone A, Münchau A, Siebner HR. (2009): Inducing homeostatic-like plasticity in human motor cortex through converging corticocortical inputs. J Neurophysiol 102(6):3180-90 http://dx.doi.org/10.1152/jn.91046.2008.

Groppa S, Siniatchkin M, Moeller F, Stephani U, Siebner H. (2009): New insights into the pathophysiology of idiopathic generalised and photosensitive epilepsies. European Journal of Neurology 16:480-485.

Bergmann TO, Groppa S, Seeger M, Mölle M, Marshall L, Siebner HR. (2009): Acute changes in motor cortical excitability during slow oscillatory and constant anodal transcranial direct current stimulation. J Neurophysiol 102(4):2303-11 http://dx.doi.org/10.1152/jn.00437.2009.

Groppa S, Werner-Petroll N, Schlaak B, van Nuenen B, Hartwigsen G, Siebner H. (2008c): Assessment of ipsilateral premotor-to-motor connectivity by highly focal TMS. Klin Neurophysiol 39(01):A59

Groppa S, Werner-Petroll N, Granert O, Hartwigsen G, Siebner H. (2008b): Probing premotor-to-motor interactions in the left hemisphere during movement selection with highly focal TMS and DTI. Akt Neurol 35(S 01):P607

Groppa S, Siebner HR, Kurth C, Stephani U, Siniatchkin M. (2008a): Abnormal response of motor cortex to photic stimulation in idiopathic generalized epilepsy. Epilepsia 49(12):2022-9 http://dx.doi.org/10.1111/j.1528-1167.2008.01709.x.

Siniatchkin M, Groppa S, Jerosch B, Muhle H, Kurth C, Shepherd AJ, Siebner H, Stephani U. (2007): Spreading photoparoxysmal EEG response is associated with an abnormal cortical excitability pattern. Brain 130(Pt 1):78-87 http://dx.doi.org/10.1093/brain/awl306.

Popa-Wagner A, Badan I, Walker L, Groppa S, Patrana N, Kessler C. (2007): Accelerated infarct development, cytogenesis and apoptosis following transient cerebral ischemia in aged rats. Acta Neuropathol 113(3):277-93 http://dx.doi.org/10.1007/s00401-006-0164-7.

Siniatchkin M, Groppa S, Siebner H, Stephani U. (2006): A single dose of sulthiame induces a selective increase in resting motor threshold in human motor cortex: A transcranial magnetic stimulation study. Epilepsy Res 72(1):18-24 http://dx.doi.org/10.1016/j.eplepsyres.2006.07.001.

Groppa S, Siniatchkin M, Siebner H, Stephani U. (2006): Reduction of motor cortex excitability by the anticonvulsant drug sulthiame: A TMS study. Epilepsia 47:123-124